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131253

Histopathological and Ultrastructural Alterations in The Renal Cortex of Albino Mice Foetuses Induced by Beta-Lactam Antibiotic 'Amoxicillin'

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Last updated: 03 Jan 2025

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Abstract

Background: The aim of this investigation was to evaluate the effect of a low and high doses (205 & 820mg/kg body weight, respectively) of the beta-lactam antibiotic amoxicillin on the kidney of maternally treated mice foetuses.
Material and Methods: Pregnant mice were allocated into three groups; the first group served as control (injected with the drug solvent) and those of the other two groups were injected intraperitoneally with two doses (205 & 820 mg/kg body weight) of amoxicillin for 8 days from day 7 till day14 during gestation. Results: The histological examination of the renal cortex of maternally treated foetuses showed erosion of the parietal cells of Bowman's capsule, hypoplasia of the mesangial cells of the glomerulus, and erosion of the epithelial cells lining the proximal and distal convoluted tubules. At the electron microscopical level, the alternations of the renal cortex of foetuses maternally treated with amoxicillin were represented by, fusion of the foot processes of the podocytes and partial destruction of the apical brush borders microvilli of the proximal convoluted tubule cells. Also, degeneration of some mitochondria, and fragmentation of the rough endoplasmic reticulum elements of the lining cells of some proximal and distal convoluted tubules were observed.
Conclusions: The uses of amoxicillin should be under restricted precautions specially for the pregnant women to avoid the hazardous impact.

DOI

10.21608/ejhm.2020.131253

Keywords

amoxicillin, kidney, Mice foetuses

Authors

First Name

Sahar A.

Last Name

Sabry

MiddleName

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Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University

Email

aharsabry84@yahoo.com

City

-

Orcid

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First Name

Heba I.

Last Name

Rashad

MiddleName

-

Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Shahin

MiddleName

-

Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University

Email

-

City

-

Orcid

-

Volume

81

Article Issue

7

Related Issue

19561

Issue Date

2020-10-01

Receive Date

2020-12-20

Publish Date

2020-10-01

Page Start

2,340

Page End

2,351

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 7_Pages 2340-2351.pdf

PDF . 823.8kB

Link

https://ejhm.journals.ekb.eg/article_131253.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=131253

Order

7

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Histopathological and Ultrastructural Alterations in The Renal Cortex of Albino Mice Foetuses Induced by Beta-Lactam Antibiotic 'Amoxicillin'

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Type

Article

Created At

22 Jan 2023