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18060

2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma

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Last updated: 30 Jan 2023

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Abstract

Background: 2'-deoxycytidine (Dcyd) is one of four major nucleosides found in the different normal body fluids due to dissolution of dead cells, and is increase in the presence of malignancy. Previous studies proved that it can be used as a marker for bladder cancer and acute lymphoblastic leukemia. The aim of this study is to assess 2'Dcyd as a possible biological marker in hepatocellular carcinoma (HCC). Methods: Four groups were evaluated for the level 2'-Dcyd as well as alpha-fetoprotein (AFP); a control group (n = 20), 20 cases of chronic liver diseases (CLD), 20 cases of hepatitis C (HCV) 60 cases of HCC. Results: In the patients with HCC, 2'-Dcyd serum level was 8-fold higher than normal level. It was 3-fold higher in HCV group. A mild increase was noted in patients with chronic liver diseases. Levels ≥ 0.14 of 2'-Dcyd had a sensitivity of 93% and specificity of 90% for diagnosis of HCC. It also recorded a sensitivity and specificity of 90% for diagnosis of HCV. Conclusions: For diagnosis of HCC, 2'-Dcyd is no better than AFP, as it is elevated in viral hepatitis C. A combination of AFP and 2'-Dcyd could provide broader information in diagnosis and treatment decision.

DOI

10.21608/ejhm.2005.18060

Authors

First Name

Wafaa Abdallah

Last Name

Ahmed

MiddleName

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Affiliation

Department of Cancer Biology

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Orcid

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First Name

Manar

Last Name

Moneer

MiddleName

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Affiliation

Department of Epidemiology and Biostatistics

Email

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City

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Orcid

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First Name

Maha M.

Last Name

Abo-Shady

MiddleName

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Affiliation

Microbiology & Immunology department, Faculty of pharmacy (girls), Al-Azhar University

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City

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Orcid

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First Name

Heba Hosny

Last Name

Mansour

MiddleName

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Affiliation

Health Radiation Research Department, National Center for Radiation Research and Technology, (NCRRT)

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City

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Orcid

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First Name

Nahed

Last Name

Abd-El-Wahab

MiddleName

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Affiliation

Department of Clinical Pathology National Cancer Institute, Cairo University, Cairo, Egyp

Email

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City

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Orcid

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First Name

Masanori

Last Name

Yoshioka

MiddleName

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Affiliation

Department of Analytical Chemistry, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan.

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City

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Orcid

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First Name

Mahmoud

Last Name

El-Merzabani

MiddleName

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Affiliation

Department of Cancer Biology (*Chemotherapy Unit)

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Orcid

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Volume

21

Article Issue

1

Related Issue

3769

Issue Date

2005-10-01

Receive Date

2018-10-31

Publish Date

2005-10-01

Page Start

191

Page End

201

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 21_Issue 1_Pages 191-201.pdf

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https://ejhm.journals.ekb.eg/article_18060.html

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https://ejhm.journals.ekb.eg/service?article_code=18060

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16

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023