Background: Crohn's disease is a multifactorial chronic inflammatory disease characterized by non-caseating granuloma formation with a tendency toward remission and relapse, it affects any part of the GIT from mouth to anus with 80% small bowel involvement, most commonly the terminal ileum, with characteristic multiple discontinuous sites involvement (skip lesions) and transmural inflammation. Aim of the Work: The purpose of this study is to highlight the value of CT in diagnosis of (CD) and its ability to assess the degree of activity and its complications. Patients and Methods: This prospective study was conducted on 87 patients with GIT symptoms where CTE was performed to evaluate its possible impact on accurate diagnosis, detection of complications and consequent guidance for management planning. It was performed in radiological department of Ain –Shams University hospital: CT Unit in the period from “July 2017 to April 2018. The patients' age ranged between (24 – 72 years) with a mean of 48 years. Results: Of the 87 patients with GIT symptoms that were highly suggestive of inflammatory bowel disease evaluated, 32 were UC, 21 were CD, 9 were other types of IBD and 25 were normal. Of the 21 CD patients evaluated, 7 were male and 14 were female. Conclusion: The role of MDCT in the diagnosis of Crohn's disease and its complications is undeniable, with a proven efficacy in identifying the enteric and extra-enteric manifestations of the disease. However, advancements in CT E protocol design have allowed increasing accuracy in diagnosis, and the acquisition of studies at a much lower radiation dose. Recommendations: Further studies on a larger scale of patients are needed to confirm the results obtained by this study.