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66829

Moringa (Moringa oleifera) Leaves' Extract and Linseed (Linum usitatissimum) Oil Ameliorate Piroxicam Induced Gastric Ulcers in Male Rats

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, …rology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)

Abstract

Gastric ulcer is a standout amongst the most significant gastrointestinal disorders affecting human worldwide. An extraordinary interest should be given to find natural medications to treat this disease. Plant extracts are more favored because of their wide safety margins and less or no adverse health impacts. The present study was conducted to assess the antiulcer activities of hydroethanolic extract of moringa leaves (500mg ̸ Kg BW) and linseed oil (0.3mL/ Kg BW) on piroxicam (30 mg ̸ Kg BW) induced gastric ulcers in Wister albino rats. Forty five adult male albino rats were allocated into five equal (9 each) groups designated as negative control, piroxicam, ranitidine, moringa and linseed oil groups. The results revealed that administration of piroxicam in a single oral dose induced gastric ulcers in rats, decrease in body weights (187.50±10.51g) and increase in gastric juice (1.64±0.24mL) with altered hematological, biochemical and histological findings. Meanwhile, oral administration of ranitidine, Moringa oleifera and linseed oil amelioratedthe ulcerogenic effect of piroxicam with curative ratios of 100, 97.5 and 100%, respectively. From the previous findings we concluded that hydroethanolic extract of moringa leaves and linseed oil were effective treatments of piroxicam induced gastric ulcer in rats. Antiulcerogenic effect of moringa and linseed oil may be attributed to their anti-inflammatory and antioxidant properties.

DOI

10.21608/zvjz.2019.14491.1057

Keywords

Gastric ulcer, Linseed, Moringa, NSAIDs, piroxicam

Authors

First Name

Hosny

Last Name

Ibrahim

MiddleName

A.

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

dr.hibrahim951@yahoo.com

City

Sharkia

Orcid

-

First Name

Noha

Last Name

Telep

MiddleName

A.

Affiliation

Pharmacology Department, Faculty of Medicine, Zagazig University, 44519, Egypt

Email

nahnohaawad@hotmail.com

City

-

Orcid

-

First Name

Manar

Last Name

Hemed

MiddleName

M.

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Email

manar_vet_16@yahoo.com

City

zagazig

Orcid

-

Volume

47

Article Issue

4

Related Issue

10094

Issue Date

2019-12-01

Receive Date

2019-07-07

Publish Date

2019-12-01

Page Start

419

Page End

431

Print ISSN

1110-1458

Online ISSN

2357-075X

Link

https://zvjz.journals.ekb.eg/article_66829.html

Detail API

https://zvjz.journals.ekb.eg/service?article_code=66829

Order

8

Type

Original Article

Type Code

601

Publication Type

Journal

Publication Title

Zagazig Veterinary Journal

Publication Link

https://zvjz.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023