Alkaloids, phenolics, tannins, glycosides, saponins, sterols, and flavonoids among other bioactive secondary metabolites were found in phytochemical analysis. It was found that cardiac glycosides were absent in leaves of the investigated plant whereas anthraquinones were not found in both leaves and stems of the plant. This study identified the plant's total (alkaloids, flavonoids, tannins, saponins and phenolic acids) percentage. The non-polar components of Euphorbia heterophylla L. were studied. GC-MS analysis of chloroform extracts and crude hexane, as well as other chromatographic separation procedures, were used to identify and characterise eight known chemicals (using MASS). These compounds: Hotrienol, 1,7-Octadiene-3,6-diol, 2,6-dimethyl, 1,7-Octadiene-3,6-diol, 2,6-dimethyl, Coumarin, Caryophyllene oxide, 2H-1-Benzopyran-2-one, 7-methoxy, Longifolenaldehyde, Hexadecanoic acid and ethyl ester.