The response of physicians to modern quality management efforts is critical as a result of increased interest in the quality of health care. The present study was designed to assess physicians' opinion and attitude toward some items of quality of care program. The study was conducted at two hospitals affiliated to Health Insurance Organization [HIO], and Ministry of Health and Population [MOHP] in Alexandria. A self-administered questionnaire was designed after thorough review of literatures. A total of 352 questionnaires were distributed in th response rate of both hospitals. Only164 physicians completed the questionnaire, with response rate of 46.6%. The results revealed that 71.3% of total physicians selected department head as the person responsible for evaluation of their performance and 83.4% of them mentioned that all hospital physicians have to set the standards for good quality of care. It appeared that 50.6% of all respondents preferred the concurrent record review as a method of performance evaluation and 62.2 of physicians considered the patient medical record valid for evaluation. Two thirds of all physicians have a positive attitude towards guidelines and only 31.1% of all physicians have a positive attitude toward acceptance of being evaluated. Bivariate analysis indicated that three variables [gender, specialty and attendance of quality training course] have significant effect on attitude scores -except that of guidelines- and that the attitude scores are significantly higher among male physicians, those with surgical specialty and those who attended quality training course. Stepwise logistic regression analyses revealed that attendance of quality training course is a common determinant affecting physicians' attitude towards Importance and acceptance of physicians performance evaluation and documentation of medical care. Age was the only independent variable that has a significant relationship with attitude towards clinical practice guidelines.