From puberty until menopause, women's biochemistry waxes and wanes to her own unique monthly rhythm, or menstruation cycle. Menstruation and a woman's menstrual cycle play a very important role in her life. This study was carried out to assess woman reaction (feeling, attitude, and practice) and knowledge toward menstruation. This study was conducted in two suburban areas namely Shebin El-Kom and Quesina and 10 rural areas from Menoufyia Governorate. A convenient sample compromised 1023 women aged between 20-45 years, single and married women, educated and none educated from urban and rural areas. The results of the study showed below half of samples received knowledge about menstruation from their mothers and sisters. Regarding feeling above two-thirds of samples had something dirty and unclean about women during menstruation.