Background: Hepatitis C is a global disease. Egypt has the largest endemic of hepatitis C virus (HCV) in the world. Objective:The aim of this study is to identify knowledge, attitude and practice about hepatitis C among patients' family caregivers in El Minia Governorate. Methods: A total of 90 main responsible family caregivers'  hepatic C patients and their were included in the study. Data were collected for a period of six months starting from March to August 2009. The study was conducted at the hepatic patients homes where the main family's caregiver are escorting. Data were collected through structured interviewed questionnaire at the patients' homes by five tools. These tools included; socio-demographic data of the study participants', as well as assessment of the patient's environment. The family caregiver participants' were assessed for their knowledge, practice and attitude by structured questionnaire, checklist and likert scale, respectively. Results: As regard patient sociodemographic date, results it showed that half of them lied in age group 35-50 years. The majority were males (73.3%). On side of the family caregivers participants', it was found that slightly more than one third were between 20-30 years (35.4%) and females represented the majority (85.6%). Environmental assessment revealed that nearly three quarters (74.4%) lived in home consisting of more than 3 rooms. As regard knowledge level; it was found that the majority of the study participants between fair and poor knowledge level (44.4% and 34.4%, respectively). While more than three-quarters of the study participants were having fair and poor practices level (43.3% and 34.5%, respectively). Concerning the study participants' attitude; about half of the sample was having agreement responses (54.5%). Statistically significant differences were found (p<0.05) between both gender in aspects of knowledge, attitude and practice. Conclusion: It was concluded that the majority of the study participants' were between fair and low level in knowledge and practice as well as positive attitude responses among half of them. It is recommended to increase patients and family caregiver's awareness about HCV transmission and prevention.