Alzheimer's disease is one of the most important diseases of aging and the most dangerous to spread, and it is expected that their number will reach about 150 million people in the coming years, which increases the risk of this disease. The average high age in many developed countries in light of recent developments has helped to spread the disease, and the study aimed at To conduct a comparative analysis between males and females of Alzheimer's patients to study the environmental and psychological variables associated with Alzheimer's disease and the mechanics of the psychological and environmental compatibility of the patients. The study used the descriptive analytical approach, and the comparison method between males and females of the study sample. Individuals with Alzheimer's patients who are reluctant to treatment in government hospitals in the Arab Republic of Egypt, and the study found: There are differences between males and females in psychosomatic disorders in favor of females, and the presence of a statistically significant reverse correlation between depression, memory and both (self-compatibility - health compatibility - social compatibility - home compatibility Overall score for compatibility.