Purpose: To evaluate patient satisfaction, the retentive characteristics, and the masticatory efficiency in maxillary single denture wearers with 3 different denture bases. Material and Methods: 40 patients; 10 dentate (control group (GC)) and 30 completely edentulous maxillary ridges patients (43-56 years) were selected for this study. The maxillary completely edentulous patients were divided into 3 groups randomly; 10 patients each and received single dentures; Group I (GI) received conventional heat cured acrylic resin (AR) followed by thermoplastic acrylic resin (TAR) then thermoplastic nylon (TN) denture base (GI:AR/TAR/TN), (GII:TAR/TN/AR) and (GIII:TN/AR/TAR). Patient satisfaction, the retentive characteristics and the masticatory efficiency were evaluated 3 months after delivery of each single denture. Results: 27 out of 30 patients had age of (mean 50 ± 3.7 years) accomplished the study. Statistically significant differences were observed in comfort and appearance, p≤ 0.05. No statistically significant differences were observed in phonetics, pain, or ease of cleaning of maxillary single denture, p>0.05. Statistically significant differences were observed in the retentive forces between (AR, TAR and TN), p≤ 0.05 except between (TN and TAR), p>0.05. Statistically significant differences were observed in the masticatory efficiency between (GC, AR, TAR and TN), p≤ 0.05 except between (TAR and TN), p>0.05. Conclusions: Maxillary single dentures with TN denture bases showed the advantage over TAR and AR denture bases in terms of comfort and appearance. Retention forces of TN and TAR were comparable and higher than that of AR denture bases. Type of denture base does not influence the masticatory efficiency of maxillary single denture wearers.