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The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease

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Last updated: 03 Jan 2025

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Abstract

Objective: to detect the effect of antithyroid drugs (ATD) on the therapeutic outcome of I-131 in hyperthyroid Graves' patients. Methods: Retrospective study was done on 200 patients with Graves' disease treated with fixed dose of radioactive iodine (RAI) (12mCi). The patients were classified into three groups: Group I (n = 70) were treated by ATDs for more than 6 months and stopped it 5 days; group II (n = 70) were treated by ATDs for more than 6 months but stopped it only for two days or less, and group III (n = 60) had never been treated with ATD before RAI treatment (control group). Results: There was a statistical significant difference in the cure rate between group I and group II (P < 0.001), group II and group III (P < 0.001), but no significant difference between group I and group III (P = 0.453) three months after RAI therapy. There was a statistical significant difference in the cure rate observed between group I and the group II (P =0.002), group II and group III (P < 0.001), but no significant difference between group I and group III (P =0.060) 6 months after RAI therapy. There was a statistical significant difference between the three groups 3 (P < 0.001), and 6 months (P < 0.001), after RAI therapy.
Conclusion: Administration of ATDs more than 6 month without discontinuation decreased response of RAI treatment in 3 and 6 months' follow-up. Discontinuation of ATDs for 5 days before RAI treatment is recommended.

DOI

10.21608/egyjnm.2017.5436

Keywords

Graves' disease, Ant thyroid drug, radioactive iodine

Authors

First Name

jehan

Last Name

younis

MiddleName

ahmed

Affiliation

department of Oncology and Nuclear medicine, faculty of medicine, Cairo university, Cairo, Egypt

Email

jehan.nuc@hotmail.com

City

cario

Orcid

-

Volume

14

Article Issue

14

Related Issue

939

Issue Date

2017-07-01

Receive Date

2018-02-21

Publish Date

2017-07-01

Page Start

28

Page End

39

Print ISSN

1687-4994

Online ISSN

2536-9113

Article File

EGYJNM_Volume 14_Issue 14_Pages 28-39.pdf

PDF . 647.4kB

Link

https://egyjnm.journals.ekb.eg/article_5436.html

Detail API

https://egyjnm.journals.ekb.eg/service?article_code=5436

Order

3

Type

Original Paper, Endocrine

Type Code

382

Publication Type

Journal

Publication Title

Egyptian Journal Nuclear Medicine

Publication Link

https://egyjnm.journals.ekb.eg/

MainTitle

The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease

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Type

Article

Created At

22 Jan 2023