Beta
ManageSearchChatDiscover
82463

Synthesis of novel 2, 3'-bipyrrole derivatives from chalcone and amino acids as antitumor agents.

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

A series of a novel 2, 3'-bipyrrole derivatives was synthesized via the reaction of chalcone, 1-(furan-2-yl)-3-(1H-pyrrol-2-yl) prop-2-enone, with different amino acids in an alkaline medium. The reaction proceeds throughout the condensation of the amino acids with chalcone to give imine intermediate consequent by decarboxylation, and then intramolecular cyclization to yield 2, 3'-bipyrrole derivatives. Antitumor activity of the newly synthesized bipyrrole derivatives was evaluated against different six cancer cell lines, and compounds 3d, 3e, 3c and 3h showed the strongest anticancer activity amongst the studied compounds. Compound 3h showed the broadest spectrum of anticancer activity against all cell lines tested. The results of this work offer a basis for further study of selected 2, 3'-bipyrrole derivatives as antitumor agents.

DOI

10.21608/ejchem.2020.27117.2560

Keywords

Amino acids, pyrrole, bipyrrole, Furan, antitumor, Chalcone

Authors

First Name

Atef

Last Name

Kalmouch

MiddleName

-

Affiliation

Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622- Dokki, Cairo, Egypt.

Email

atefkalmoush@gmail.com

City

-

Orcid

0000-0002-0680-5507

First Name

Mohamed

Last Name

Rdwan

MiddleName

-

Affiliation

Department of Applied Organic Chemistry, National Research Center, Dokki 12622, Egypt. Department of Chemistry, College of Science, Qassim University, Buraydah, Kingdom of Saudi Arabia.

Email

m1radwan@yahoo.com

City

Dokki -Giza

Orcid

0000-0002-2151-6802

First Name

Mervat

Last Name

M. Omran

MiddleName

-

Affiliation

Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University.

Email

dr.mervatomran@gmail.com

City

-

Orcid

0000-0003-1643-0104

First Name

Marwa

Last Name

Sharaky

MiddleName

-

Affiliation

Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University.

Email

marwasharaky80@gmail.com

City

-

Orcid

-

First Name

Gaber

Last Name

O. Moustafa

MiddleName

-

Affiliation

Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt. Nahda University, New Benisuef City, Postal code (62521), Beni sueif, Egypt.

Email

gosman79@gmail.com

City

-

Orcid

-

Volume

63

Article Issue

11

Related Issue

18119

Issue Date

2020-11-01

Receive Date

2020-04-02

Publish Date

2020-11-01

Page Start

4,409

Page End

4,421

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 11_Pages 4409-4421.pdf

PDF . 737.8kB

Link

https://ejchem.journals.ekb.eg/article_82463.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=82463

Order

21

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis of novel 2, 3'-bipyrrole derivatives from chalcone and amino acids as antitumor agents.

Details

Type

Article

Created At

22 Jan 2023