Hyperprolactinaemia is areal challenge for gynecologist and endocrinologists ,bromocriptine was used for treating hyperprolactinaemia ,bromocriptine associated with many side effect this study aimed to compare clinical response , side effects and tolerability of vaginal versus oral bromocriptine for treatment of hyperprolactinemia
Patients and methods: Non randomized controlled clinical trial at the out-patient Clinic of Obstetrics and Gynecology,Zagazig University and Zifta general hospital (ministry of health). This study included 87 patients who suffered hyperprolactinaemia .Patients divided into 3 groups:Group A included 29 patients who used bromocriptine 2.5mg tablets vaginally once daily for one month .Group B included 29 patients who administrated bromocriptine 2.5mg vaginal suppositories once daily for one month. Group C included 29 patients who received bromocriptine 2.5mg tablet orally twice daily for one month.Serum prolactin was measured before and after therapy in all cases.
Results:Bromocriptine was effective in decreasing level of prolactin whether used orally or vaginally. Vaginal bromocriptine suppositories application was associated with minimal side effect both local and general .Nausea was the most frequent side effect with oral tablets ,while excessive vaginal discharge and dyspareunia was the most occurring local side effect. Most side effect in three groups occur within the first 10 day after starting therapy.
Conclusions: Bromocriptine is avery effective drug in treating hyperprolactinaemia, restoration of normal ovulation ,improvement of mastalgia and galactorrhea .Based on our results vaginal bromocriptine suppositories is associated with minimal local and systemic side effect when compared with bromocriptine tablets when used orally or vaginally.
Key words: Hyperprolactinaemia ,Bromocriptine, oral, vagina.