Abstract Background: Acne is a common inflammatory skin disor-der manifested by comedones, papules and pustules mainly at face. Acne may be complicated by nodules, cysts and residual scarring that affect life quality. Aim of Study: Was to determine the impact of acne on health related quality of life comparing with normal healthy control. Patients and Methods: The current study included 400 subjects aged from 13 to 18 years old. They were divided into patients' group and control group, each included 200 subjects with age and sex matched. The patients group with mean age of (15.6±1.54); the female patients constituted 113 (56.5%). According to acne severity, the patient group included moderate acne (117) patients and severe acne in 83 patients. The control group included 114 (57%) females. Full history taking, general examination including measuring of BMI, dermatologic ex-amination to determine site, extent and grading. Results: Acne negatively affects self-perception in com-parison with control while no difference in social role between cases and control. There is a positive correlation between self-perception and the other domains, while there is a negative correlation between acne symptoms and other domains of quality of life. Conclusions: Acne can affects social and psychologic impact on life quality. Recommendations: Assessment of life quality in acne patients is a must and should be taken into consideration before deciding line of treatment.