Objectives of this study was to evaluate odontometric linear measurements obtained from CBCT software including mesiodistal, tooth length dimensions and enamel thickness of the mandibular canine and mandibular first molar and arch measurements for sexual dimorphism in Egyptian population sample. Material and Methods: The study was carried out on 100 patients who visited the department of oral and maxillofacial radiology, Fayoum University for dental treatments. The study sample were grouped into two groups, group A (50 males) and group B (50 females) aged between 18-25 years old. The teeth which were selected for linear measurements using CBCT in the present study were 100 mandibular permanent canines (Lower 3) and 100 mandibular permanent 1st molar (Lower 6), for each group respectively. The linear measurements were taken on crown width and height, Enamel thickness, arch depth and width. Results: There was a highly significant difference between Male and Female for odontometric measurements of mandibular right and left canines and 1st molars including (CWL3, CLL3, CWL6 and CLL6) while enamel thickness measurements showed non-significant differences between males and females including (ETL3 at cusp tip, ETML6, ETDL6 and ETL6 at mesio-lingual cusp tip). Arch measurements including (ICW, IMW through fossa and IMW through contact) showed high significant differences between males and females. Conclusion: Odontometric parameters including mandibular canine, mandibular first molar crown width and length, inter-canine width and inter-molar width measurements based on CBCT imaging show highly significant gender difference. Thus, the parameters can be simple and reliable sexual dimorphism for medicolegal purpose.