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246931

Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience

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Last updated: 01 Jan 2025

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Abstract

Background: Primary vaginal malignancies are rare in children. Their management has evolved during the last decades from radical surgery to neoadjuvant chemotherapy followed by local control with conservative surgery or radiotherapy.
Aim: To describe the presentation, management, and outcome of pediatric vaginal malignancies.
Methods: Retrospective review of the medical records of children with 1ry vaginal malignancies who had been treated at the Children's Cancer Hospital Egypt (CCHE)-57357 from June 2007 till December 2018.
Results: During the 11 years, 34 pediatric patients with 1ry vaginal malignancies were identified. The histopathology was rhabdomyosarcoma (RMS) in 19 (55.9%) patients, germ cell tumor (GCT) in 13 (38.2%), and clear cell adenocarcinoma (CCA) in two (5.9%). Vaginal bleeding was the presenting symptom in 65% of the patients. The 5-year overall survival and event-free survival rates were 73.7% and 77.8%, respectively, in RMS patients. In GCT patients, the 5-year overall survival and event-free survival rates were 84.6% and 61.5%, respectively. One of the two CCA patients died because of disease progression and the other was alive with progressive disease.
Conclusions: Primary vaginal tumors are rare in children and generally have a good prognosis. Treatment with chemotherapy only or with either conservative surgery or radiotherapy may achieve an excellent outcome in pediatric primary vaginal RMS and GCT.

DOI

10.21608/resoncol.2021.73214.1142

Keywords

Clear cell adenocarcinoma, Germ cell tumor, Pediatric, Rhabdomyosarcoma, Vagina

Authors

First Name

Enas

Last Name

El Nadi

MiddleName

-

Affiliation

Department of Pediatric Oncology, Children's Cancer Hospital Egypt, Cairo, Egypt , Medical Oncology Department, Faculty of Medicine, Beni‐Suef University, Beni-Suef, Egypt

Email

elnadienas@gmail.com

City

New Cairo

Orcid

0000-0001-2345-6789

First Name

Mariam

Last Name

Elsherif

MiddleName

-

Affiliation

Department of Pediatric Oncology, Children's Cancer Hospital Egypt, Cairo, Egypt

Email

mariam.elsherif@57357.org

City

-

Orcid

-

First Name

Madeeha

Last Name

Elwakeel

MiddleName

-

Affiliation

Department of Radiology, Children's Cancer Hospital Egypt, Cairo, Egypt , National Cancer Institute, Cairo University, Cairo, Egypt

Email

madeha.elwakeel@57357.org

City

-

Orcid

-

First Name

Hala

Last Name

Taha

MiddleName

-

Affiliation

Department of Pathology, Children's Cancer Hospital Egypt, Cairo, Egypt , National Cancer Institute, Cairo University, Cairo, Egypt

Email

hala.taha@57357.org

City

-

Orcid

-

First Name

Maged

Last Name

Elshafiey

MiddleName

-

Affiliation

Department of Surgery, Children's Cancer Hospital Egypt, Cairo, Egypt , National Cancer Institute, Cairo University, Cairo, Egypt

Email

majed.elshafeiy@57357.org

City

-

Orcid

-

First Name

Gehad

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Surgery, Children's Cancer Hospital Egypt, Cairo, Egypt , Department of Surgery, Faculty of Medicine, Helwan University, Cairo, Egypt

Email

gehad.ahmed@57357.org

City

-

Orcid

-

First Name

Mohamed

Last Name

Zagloul

MiddleName

S.

Affiliation

Department of Radiation Therapy, Children's Cancer Hospital Egypt, Cairo, Egypt , National Cancer Institute, Cairo University, Cairo, Egypt

Email

mohamed.saad@57358.org

City

-

Orcid

-

First Name

Dina

Last Name

Elgalaly

MiddleName

-

Affiliation

Department of Research, Children's Cancer Hospital Egypt, Cairo, Egypt

Email

dina.elgalaly@57357.org

City

-

Orcid

-

First Name

Elham

Last Name

Khaled

MiddleName

-

Affiliation

Department of Research, Children's Cancer Hospital Egypt, Cairo, Egypt

Email

ilham.khaled@57357.org

City

-

Orcid

-

First Name

Sahar

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pediatric Oncology, Children's Cancer Hospital Egypt, Cairo, Egypt , National Cancer Institute, Cairo University, Cairo, Egypt

Email

sahar.ahmed@57357.org

City

-

Orcid

-

Volume

18

Article Issue

1

Related Issue

35384

Issue Date

2022-06-01

Receive Date

2021-04-20

Publish Date

2022-06-01

Page Start

10

Page End

18

Print ISSN

2357-0687

Online ISSN

2357-0695

Article File

RESONCOL_Volume 18_Issue 1_Pages 10-18.pdf

PDF . 485.7kB

Link

https://resoncol.journals.ekb.eg/article_246931.html

Detail API

https://resoncol.journals.ekb.eg/service?article_code=246931

Order

2

Type

Original Article

Type Code

200

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience

Details

Type

Article

Created At

22 Jan 2023