Beta
3520

Survival of High Grade Glioma Patients Treated by Three Radiation Schedules with Chemotherapy: A Retrospective Comparative Study

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

-

Abstract

Background: High grade glioma (HGG) is the most common primary malignant brain tumor. Radiotherapy (RT) plays an important role in the treatment of this tumor.
Aim: To compare the survival rates of HGG patients treated by conventional RT and those treated by hypofractionated or hyperfractionated RT combined with chemotherapy in two centers in Upper Egypt.
Methods: Data of HGG patients from two cancer care facilities in Upper Egypt who were treated by surgery followed by RT and temozolomide (TMZ) in the period between 2007 and 2012 were reviewed. Radiotherapy schedules were either conventional RT (60 Gy in 30 fractions over 6 weeks, group A) or hypofractionated RT (45 Gy in 15 fractions over 3 weeks, group B) or hyperfractionated RT (64.8 Gy in, 1.2 Gy/fraction, 2 fractions/day, group C) with ±concurrent TMZ and adjuvant TMZ. Progression-free survival (PFS) and overall survival (OS) of patients after receiving the different types of RT treatment were evaluated.
Results: Forty-eight patients with grade III or IV HGG were identified. They were classified into 3 groups (A, B and C) that included 17, 16 and 15 patients, respectively. The median PFS were 6, 9 and 8 months (p= 0.354) and the median OS were 11, 12 and 14 (p= 0.760) for group A, B and C, respectively. Late RT toxicity was not different between the 3 groups.
Conclusion: The three radiation schedules had a similar efficacy in adult HGG patients.

DOI

10.21608/resoncol.2017.552.1022

Keywords

glioma, chemoradiation, Radiation, External beam, Hypo-fractionation

Authors

First Name

Samir

Last Name

S. Mohamed

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Assiut University, Egypt

Email

-

City

-

Orcid

-

First Name

Hamza

Last Name

A. Hamza

MiddleName

-

Affiliation

Radiotherapy Department, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed Alaa-Eldeen

Last Name

Mohamed

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Assiut University, Egypt

Email

malaaassiut@gmail.com

City

-

Orcid

-

First Name

Amany

Last Name

G. Ali

MiddleName

-

Affiliation

Radiotherapy Department, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Egypt

Email

-

City

-

Orcid

-

Volume

13

Article Issue

1

Related Issue

607

Issue Date

2017-06-01

Receive Date

2017-04-05

Publish Date

2017-06-01

Page Start

18

Page End

22

Print ISSN

2357-0687

Online ISSN

2357-0695

Link

https://resoncol.journals.ekb.eg/article_3520.html

Detail API

https://resoncol.journals.ekb.eg/service?article_code=3520

Order

5

Type

Original Article

Type Code

200

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023