Our eyes are increasingly exposed to light from the light emitting diode (LED) of video display terminals (VDT) which contain much blue light. VDTs are equipped with televisions, personal computers, and smartphones.; hence it is so important to know the implications of LED radiations on the human visual system. The present study is designed to evaluate the influence of blue and green LEDs on rat's retina. Forty-six female Wistar albino rats weighing 250-300 g classified into 3 groups. Group (1) served as control. Group (II) exposed to (461nm) blue LED (12 hr light-dark cycle) for 3, 7, 14 and 21days. Group (III) exposed to (525.9 nm) green LED (12 hr light-dark cycle) for 3, 7, 14 and 21days. At the end of each period, electroretinogram (ERG) and microscopic examination are carried out. The results indicated that there was no significant effect for the green LED on the ERG, and microscopic examination illustrates mild changes.   After exposure of rat's retina to blue LED, there is a reduction in a- and b- wave amplitudes, and the histopathological examination illustrates severe changes. The data suggest that the blue LED may cause retinal toxicity. Therefore, it is very important to recognize the hazard of LED radiations that affects vision and take appropriate precautions for the eye safetyKeywords: Light emitting diodes, Electroretinogram, histopathological examination.