The west Edfu area lies among of El-Galaba basin, which is considered an important part of the Egyptian 1.5 million feddans of the national reclamation project. This area attracted the investors for reclamation and development of new settlements. The groundwater is the only water source for such integrated development. Twelve groundwater samples were collected from west Edfu aquifer wells located in the western desert to evaluate the quality of these well waters for irrigation. The area under investigation is located between latitudes 24^o 40' 00" – 25^o 7' 22" N and longitudes 32^o 32^' 52^" – 32^o 50' 00" E.  The groundwater chemical parameters (EC_w, TDS, pH, Na⁺, K⁺, Ca²⁺, Mg²⁺, Cl^- , HCO₃^-, Fe²⁺,Pb and Cu²⁺) of the investigated aquifer wells were determined. Irrigation indices such as total hardness (TH), sodium adsorption ratio (SAR), residual sodium carbonate (RSC), soluble sodium percentage (SSP), magnesium hazard (MH), residual sodium bicarbonate (RSCB), permeability index (PI), kelley's index (KI) were also evaluated. According to Ayers and Westcot, (1994), all the studied groundwater samples had pH values that are acceptable for irrigation. The concentration of the cations in these samples are decreased in the order of Na⁺> Ca²⁺> Mg²⁺> K⁺ and for anions was in the order of Cl^-> HCO₃^2-. The EC and TDS values of the groundwater samples ranged from 1680 to 9045 μS/cm and 870 to 4700 mg/L, respectively. The SAR of these samples varied from 5.31 to 8.91 meq/L. The PI, KI, SSP and MH differed from 42.90 to 71.49 %, 0.76 to 2.65, 46.59 to 77.78 % and 45.49 to 78.94 %, respectively. The concentration of both iron and copper of these groundwater samples is high in the eastern part of the study area while, the concentration of lead is high in the central part. In general, some well groundwater in the studied area is suitable for irrigation.