The main objectives of this study were to determine perception level of the cattle breeders concerning shared diseases between human and animal, also determine perception level of the respondents concerning protection methods from shared diseases between human and animal, as well as determine the independent variables affecting perception levels both shared diseases and protection methods from it, besides identify the respondents information sources regarding shared diseases.         Six villages were selected randomly from three districts in kafr el-sheikh governorate. A random sample consisted of 190 respondents were chosen from cattle breeders whom own three and more from cattle, Data were collected through personal interview pre-tested questionnaire, Arithmetic means, simple correlation coefficient, and multiple correlation & regression analysis (step-wise) were used to analyze data, in addition to frequencies, percentages and weighted Means. The results revealed that the perception level of  33,7% of respondents was low, 43,1% was moderate concerning shared diseases between human and animal,as well as 33,7%, 33,15% from respondent's perception levels were low and moderate respectively regarding protection methods from shared diseases.   Findings of multiple correlation & regression analysis showed that five independent variables significantly affected respondent's perception degree concerning shared diseases between human and animal and explained 57, 4% from its variance which were: respondent's knowledge degree with the healthy characteristics of animal, respondent's participating degree(informal) in the developmental projects, respondent's attitude degree towards protection from shared diseases between human and animal, degree of respondent's education, and size of farm animal holding According to step- wise there were three independent variables significantly affected respondent's perception degree concerning protection methods from shared diseases and explained 63,7%% from its variance which were: respondent's perception degree of shared diseases between human and animal, degree of respondent's exposure and benefit from information sources, and degree of respondent's wife education. There were fifteen information sources could be ranked in descending order according to degree of benefit from it by respondents (self estimation) as follows: veterinary office (clinic), governmental veterinary unities, friends & neighbors, cattle's market, senior breeders, cattle's examiner (checker), while agricultural extension agent and animal production specialist were come in late order.       The main objectives of this study were to determine perception level of the cattle breeders concerning shared diseases between human and animal, also determine perception level of the respondents concerning protection methods from shared diseases between human and animal, as well as determine the independent variables affecting perception levels both shared diseases and protection methods from it, besides identify the respondents information sources regarding shared diseases.         Six villages were selected randomly from three districts in kafr el-sheikh governorate. A random sample consisted of 190 respondents were chosen from cattle breeders whom own three and more from cattle, Data were collected through personal interview pre-tested questionnaire, Arithmetic means, simple correlation coefficient, and multiple correlation & regression analysis (step-wise) were used to analyze data, in addition to frequencies, percentages and weighted Means. The results revealed that the perception level of  33,7% of respondents was low, 43,1% was moderate concerning shared diseases between human and animal,as well as 33,7%, 33,15% from respondent's perception levels were low and moderate respectively regarding protection methods from shared diseases.