Th The present study was initiated to show the effect of hive warming on the quantity and quality of produced hanone honey in El-Gable Al-Akhader, Lybia. The results indicated that the hive covering led to  increase of the quantity of capped cells and ripened honey which enhance and encourage the worker bees activities for gathering, storing and honey ripening. It was found that warming the hive increased the quantity and quality of honey in those covered hives than the uncovered ones. Three concentrations of honey produced from either capped or uncapped cells (25, 50 and 75%) in comparison with a standard antibiotic were tested against E. coli . The honey collected from capped cells inhibited the bacteria E. coli, better than the honey collected from other uncapped cells. The results also indicated that as the concentration of capped cells honey in a solution increased, the inhibition of the bacterium E. coli  also increased