TWO EXPERIMENTS were conducted during the 2008 and 2009 summer seasons to investigate the effect of different water quality (Nile water, untreated industrial derange and industrial drainage bio-remediated with Effective Microorganisms (EM)), and two plant spacing (45 and 60 cm between plants) and Effective Microorganisms foliar application (0, 20 and 40 ppm) in addition to their interactions on Sesbania (Sesbania aegyptiaca [Poir]) growth, productivity and water quality. Sesbania studied growth characters included plant height, number of second branches, second branches fresh and dry weights, main stem diameter, weight of main stem, branching level, crude protein and crude fiber . The studied water quality indicators included (ph., Biological Oxygen Demand (BOD) and Chemical Oxygen Demand (COD)). Results indicated that the industrial drainage water bioremediated with EM improved the industrial drainage properties significantly. The irrigation with Nile water gave the highest observations of Sesbania growth characters, followed by industrial drainage bio-remediated with EM and the untreated industrial derange, respectively. Concerning plant spacing the highest Sesbania growth characters obtained at 60 cm between plants except 2^nd branches fresh and dry weights and crude protein which gave the highest observations at 45 cm distance. Similar, trend was obtained from applying EM as a foliar treatment as 20 ppm. The second order and third order interactions were mostly significant. The superior interaction concerning Sesbania growth was obtained by (EM industrial water bioremediated with EM × 60 cm line spacing × 20 ppm EM foliar application).